Serb Novak Djokovic and Argentine Guillermo Canas will go head-to-head for a spot in the Pacific Life Open quarterfinals after the two players took different paths to victory in their third round matches, Monday evening in Indian Wells.

The third-seeded Djokovic needed just 69 minutes to defeat German Philipp Kohlschreiber 6-3, 6-2, while No. 16 seed Canas battled to the 6-3, 6-7(1), 6-2 win against compatriot Juan Monaco in two hours and 39 minutes.

Both players made headlines last year in Indian Wells – Djokovic with his run to the final and Canas with his second round upset of three-time defending champion Roger Federer – and carried the momentum to Miami, where they faced off in the title match. Djokovic won that match in three sets to clinch his first ATP Masters Series shield.

Djokovic said he would once again need to play his top game against Canas: “He's the kind of player that not going to give you a lot of free points, unforced errors.  He's going to make you work for it. I expect that, I know.”

The Djokovic-Canas match joins a blockbuster line-up of fourth round matches on tap at the Indian Wells Tennis Garden, includes defending champion Rafael Nadal versus Australian Open finalist Jo-Wilfried Tsonga, and World No. 8 Richard Gasquet versus No. 9 James Blake. (More)

Swiss Stanislas Wawrinka and Korean Hyung-Taik Lee ensured there would be an unseeded quarterfinalist with each recording their second straight upset of a seeded player.

Wawrinka, who ousted No. 10 Tomas Berdych in the second round, followed with a 6-3, 6-7(1), 6-0 win over 18th-seeded Cypriot Marcos Baghdatis. The Swiss No. 2 is making his second appearance in Indian Wells, and reached the second round in his debut in 2006.

Lee was forced to go the distance in his match against World No. 5 David Ferrer after the Spaniard clawed his way back from down a set and two breaks. The 32-year-old Lee maintained his composure to seal the 7-6(5), 6-7(5), 7-6(3) win in two hours and 50 minutes. It marked just his fifth career win in 30 matches against Top 10 players.

Prior to this week, Lee had lost in the first round of his four previous Indian Wells appearances. He opened his 2008 campaign with a win over Frenchman Michael Llodra and staged a successful comeback against No. 23 seed Jarkko Nieminen in the second round.